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dc.contributor.authorGustavo Pacheco-Lopez, 0000-0002-3458-197X-
dc.contributor.otherBoitard, Chloé-
dc.contributor.otherParkesL, Shauna L-
dc.contributor.otherCavaroc, Amandine-
dc.contributor.otherTantot, Frédéric-
dc.contributor.otherNathalie, Castanon-
dc.contributor.otherLayé, Sophie-
dc.contributor.otherTronel, Sophie-
dc.contributor.otherCoutureau, Etienne-
dc.contributor.otherFerreira, Guillaume-
dc.date.accessioned2018-05-30T22:41:17Z-
dc.date.available2018-05-30T22:41:17Z-
dc.date.issued2016-
dc.identifier.otherhttps://doi.org/10.3389/fnbeh.2016.00225-
dc.identifier.urihttp://hdl.handle.net/20.500.12222/39-
dc.descriptionIn addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence in adolescents is particularly alarming since this is a period of ongoing maturation for brain structures (including the hippocampus and amygdala) and for the hypothalamic-pituitary-adrenal (HPA) stress axis, which is required for cognitive and emotional processing. We recently demonstrated that adolescent, but not adult, high-fat diet (HF) exposure leads to impaired hippocampal function and enhanced amygdala function through HPA axis alteration (Boitard et al., 2012, 2014, 2015). Here, we assessed whether the effects of adolescent HF consumption on brain function are permanent or reversible. After adolescent exposure to HF, switching to a standard control diet restored levels of hippocampal neurogenesis and normalized enhanced HPA axis reactivity, amygdala activity and avoidance memory. Therefore, while the adolescent period is highly vulnerable to the deleterious effects of diet-induced obesity, adult exposure to a standarddiet appears sufficient to reverse alterations of brain function.es_MX
dc.formatapplication/pdfes_MX
dc.languageenges_MX
dc.publisherFrontiers Mediaes_MX
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.titleSwitching adolescent high-fat diet to adult control diet restores neurocognitive alterationses_MX
dc.typearticlees_MX
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.rights.licenseinfo:eu-repo/semantics/openAccesses_MX
dc.subject.keywordsHippocampuses_MX
dc.subject.keywordsAmygdalaes_MX
dc.subject.keywordsObesityes_MX
dc.subject.keywordsLearninges_MX
dc.subject.keywordsAdolescencees_MX
dc.subject.keywordsNeurogenesises_MX
dc.subject.keywordsRates_MX
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_MX
dc.coveragePTes_MX
dc.audienceresearcherses_MX
dc.identificador.materia3es_MX
dc.source.otherFrontiers in Behavioral Neuroscience, vol.10 (2016)es_MX
dc.source.otherISSN: 0735-7044es_MX
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