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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.12222/38
Título : New insights on retrieval-induced and ongoing memory consolidation : lessons from arc
Autor(es) : Kioko Guzmán-Ramos, 0000-0002-5180-4127; Pascal Morin, Jean, 0000-0001-8221-4982
Autor(es) sin ID: Bermudez Rattoni, Federico
Fecha de publicación : 2015
Tipo de resultado Científico: article
Materia o Disciplina: BIOLOGÍA Y QUÍMICA
Palabras clave: Memory Formation; ARC Protein; Neuronal Plasticity; Synapses; Neuronal Network
Descripción : The mainstream view on the neurobiological mechanisms underlying memory formation states that memory traces reside on the network of cells activated during initial acquisition that becomes active again upon retrieval (reactivation). These activation and reactivation processes have been called “conjunctive trace.” This process implies that singular molecular events must occur during acquisition, strengthening the connection between the implicated cells whose synchronous activity must underlie subsequent reactivations. The strongest experimental support for the conjunctive trace model comes from the study of immediate early genes such as c-fos, zif268, and activity-regulated cytoskeletal-associated protein. The expressions of these genes are reliably induced by behaviorally relevant neuronal activity and their products often play a central role in long-term memory formation. In this review, we propose that the peculiar characteristics of Arc protein, such as its optimal expression after ongoing experience or familiar behavior, together with its versatile and central functions in synaptic plasticity could explain how familiarization and recognition memories are stored and preserved in the mammalian brain.
Editor: Hindawi Publishing Corporation
URI : http://hdl.handle.net/20.500.12222/38
Condiciones de licencia: https://creativecommons.org/licenses/by/3.0/
Fuente: Neural Plasticity, vol.2015 (2015)
ISSN: 2090-5904
Aparece en las colecciones: Artículos Científicos

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