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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.12222/35
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dc.contributor.authorGustavo Pacheco-Lopez, 0000-0002-3458-197X-
dc.contributor.otherSchober, Gundrun-
dc.contributor.otherArnold, Myrtha-
dc.contributor.otherBirtles, Susan-
dc.contributor.otherBuckett;, Linda K.-
dc.contributor.otherTurnbull, Andrew V.-
dc.contributor.otherLanghans, Wolfgang-
dc.contributor.otherMansouri, Abdelhak-
dc.date.accessioned2018-05-30T18:23:20Z-
dc.date.available2018-05-30T18:23:20Z-
dc.date.issued2013-
dc.identifier.urihttp://hdl.handle.net/20.500.12222/35-
dc.descriptionAcyl CoA: diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final step in triacylglycerol (TAG) synthesis and is highly expressed in the small intestine. Because DGAT-1 knockout mice are resistant to diet-induced obesity, we investigated the acute effects of intragastric (IG) infusion of a small molecule diacylglycerol acyltransferase-1 inhibitor (DGAT-1i) on eating, circulating fat metabolites, indirect calorimetry, and hepatic and intestinal expression of key fat catabolism enzymes in male rats adapted to an 8 h feeding-16 h deprivation schedule. Also, the DGAT-1i effect on fatty acid oxidation (FAO) was investigated in enterocyte cell culture models. IG DGAT-1i infusions reduced energy intake compared with vehicle in high-fat diet (HFD)-fed rats, but scarcely in chow-fed rats. IG DGAT-1i also blunted the postprandial increase in serum TAG and increased β-hydroxybutyrate levels only in HFD-fed rats, in which it lowered the respiratory quotient and increased intestinal, but not hepatic, protein levels of Complex III of the mitochondrial respiratory chain and of mitochondrial hydroxymethylglutaryl-CoA synthase. Finally, the DGAT-1i enhanced FAO in CaCo2 (EC50 = 0.3494) and HuTu80 (EC50 = 0.00762) cells. Thus, pharmacological DGAT-1 inhibition leads to an increase in intestinal FAO and ketogenesis when dietary fat is available. This may contribute to the observed eating-inhibitory effect.es_MX
dc.formatapplication/pdfes_MX
dc.languageenges_MX
dc.publisherUniversidad Autónoma Metropolitana. Unidad Lermaes_MX
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.titleDiacylglycerol acyltransferase 1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in ratses_MX
dc.typepreprintes_MX
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.rights.licenseinfo:eu-repo/semantics/openAccesses_MX
dc.subject.keywordsTriacilglicerol;es_MX
dc.subject.keywordsCetogénesis;es_MX
dc.subject.keywordsIntestino delgado;es_MX
dc.subject.keywordsEnterocitos;es_MX
dc.subject.keywordsDieta rica en grasas;es_MX
dc.subject.keywordsAlimentación;es_MX
dc.subject.keywordsAcil CoA:es_MX
dc.subject.keywordsDiacilglicerol aciltransferasa-1Triacylglycerol;es_MX
dc.subject.keywordsKetogenesis;es_MX
dc.subject.keywordsAcyl CoA iacylglycerol acyltransferase-1es_MX
dc.subject.keywordsSmall intestine;es_MX
dc.subject.keywordsEnterocytes;es_MX
dc.subject.keywordsHies_MX
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_MX
dc.coverageMXes_MX
dc.audienceresearcherses_MX
dc.identificador.materia3es_MX
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