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dc.contributor.authorGustavo Pacheco-Lopez, 0000-0002-3458-197X-
dc.contributor.otherElorza Ávila, Ana Rosa-
dc.contributor.otherReyes Lagos, José Javier-
dc.contributor.otherHadamitzky, Martin-
dc.contributor.otherPeña Castillo, Miguel Ángel-
dc.contributor.otherEcheverría, Juan Carlos-
dc.contributor.otherOrtiz Pedroza, María del Rocío-
dc.contributor.otherLückemannc, Laura-
dc.contributor.otherSchedlowskic, Manfred-
dc.date.accessioned2018-06-28T01:24:04Z-
dc.date.available2018-06-28T01:24:04Z-
dc.date.issued2016-
dc.identifier.otherhttp://dx.doi.org/10.1016/j.resp.2016.10.008-
dc.identifier.urihttp://hdl.handle.net/20.500.12222/180-
dc.descriptionBackgraund: Recent findings concerning oxytocin indicate its anti-inflammatory, cardioprotective and parasympathetic modulating properties. In this study, we investigated the effects of systemically applied oxytocin on the cardiorespiratory activity in a rodent model of moderate endotoxemia. Methods:Telemetrically recorded electrocardiogram (ECGs) from animals which received lipopolysaccharide (LPS); oxytocin (Ox); lipopolysaccharide + oxytocin (LPS + Ox), or vehicle (V) were analyzed using the ECG-derived respiration (EDR) technique to estimate the respiratory rate. The mean R–R interval and the spectral parameters of heart rate variability (HRV), such as the natural logarithm of the high frequency (lnHF) and low frequency (lnLF) components were also estimated up to 24 h after treatment. Results: The endotoxemic animals (LPS) showed an elevated respiratory rate as well as a reduced mean R–R interval, lnHF and lnLF components compared to controls (V) from +5 to +12 h after the treatment. The administration of oxytocin significantly attenuated the hyperventilation produced by the LPS-induced endotoxemia (LPS + Ox) and restored the values of the mean R–R interval and such spectral parameters at different time points. Conclusions: Our results support the existence of a link among the respiratory, cardiovascular, and immune systems in which oxytocin seems to act as a potential cardioprotective peptide by favoring cardiac cholinergic autonomic coupling. As a result, oxytocin diminished animal’s endotoxemic tachypnea and restored the cardiorespiratory interactions, which was indicated by the spectral components of HRV.es_MX
dc.formatapplication/pdfes_MX
dc.languageenges_MX
dc.publisherUniversidad Autónoma Metropolitana. Unidad Lermaes_MX
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.titleOxytocin’s role on the cardiorespiratory activity of endotoxemic ratses_MX
dc.typepreprintes_MX
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.rights.licenseinfo:eu-repo/semantics/openAccesses_MX
dc.subject.keywordsECG-derived Respirationes_MX
dc.subject.keywordsAnti-inflammatory Cholinergic Pathway HRVes_MX
dc.subject.keywordsOxytocines_MX
dc.subject.keywordsLPSes_MX
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_MX
dc.coverageMXes_MX
dc.audienceresearcherses_MX
dc.identificador.materia3es_MX
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