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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.12222/180
Título : Oxytocin’s role on the cardiorespiratory activity of endotoxemic rats
Autor(es) : Gustavo Pacheco-Lopez, 0000-0002-3458-197X
Autor(es) sin ID: Elorza Ávila, Ana Rosa; Reyes Lagos, José Javier; Hadamitzky, Martin; Peña Castillo, Miguel Ángel; Echeverría, Juan Carlos; Ortiz Pedroza, María del Rocío; Lückemannc, Laura; Schedlowskic, Manfred
Fecha de publicación : 2016
Tipo de resultado Científico: preprint
Materia o Disciplina: MEDICINA Y CIENCIAS DE LA SALUD
Palabras clave: ECG-derived Respiration; Anti-inflammatory Cholinergic Pathway HRV; Oxytocin; LPS
Descripción : Backgraund: Recent findings concerning oxytocin indicate its anti-inflammatory, cardioprotective and parasympathetic modulating properties. In this study, we investigated the effects of systemically applied oxytocin on the cardiorespiratory activity in a rodent model of moderate endotoxemia. Methods:Telemetrically recorded electrocardiogram (ECGs) from animals which received lipopolysaccharide (LPS); oxytocin (Ox); lipopolysaccharide + oxytocin (LPS + Ox), or vehicle (V) were analyzed using the ECG-derived respiration (EDR) technique to estimate the respiratory rate. The mean R–R interval and the spectral parameters of heart rate variability (HRV), such as the natural logarithm of the high frequency (lnHF) and low frequency (lnLF) components were also estimated up to 24 h after treatment. Results: The endotoxemic animals (LPS) showed an elevated respiratory rate as well as a reduced mean R–R interval, lnHF and lnLF components compared to controls (V) from +5 to +12 h after the treatment. The administration of oxytocin significantly attenuated the hyperventilation produced by the LPS-induced endotoxemia (LPS + Ox) and restored the values of the mean R–R interval and such spectral parameters at different time points. Conclusions: Our results support the existence of a link among the respiratory, cardiovascular, and immune systems in which oxytocin seems to act as a potential cardioprotective peptide by favoring cardiac cholinergic autonomic coupling. As a result, oxytocin diminished animal’s endotoxemic tachypnea and restored the cardiorespiratory interactions, which was indicated by the spectral components of HRV.
Editor: Universidad Autónoma Metropolitana. Unidad Lerma
URI : http://hdl.handle.net/20.500.12222/180
Condiciones de licencia: http://creativecommons.org/licenses/by-nc-nd/4.0/
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