Exogenous oxytocin reduces signs of sickness behavior and modifies heart rate fluctuations of endotoxemic rats

Gustavo Pacheco-Lopez, 0000-0002-3458-197X

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.12222/179

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Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Gustavo Pacheco-Lopez, 0000-0002-3458-197X	-
dc.contributor.other	Reyes Lagos, José Javier	-
dc.contributor.other	Hadamitzky, Martin	-
dc.contributor.other	Peña Castillo, Miguel Ángel	-
dc.contributor.other	Echeverría Arjonilla, Juan Carlos	-
dc.contributor.other	Bösche, Katharina	-
dc.contributor.other	Lückemann, Laura	-
dc.contributor.other	Schedlowski, Manfred	-
dc.date.accessioned	2018-06-28T01:03:28Z	-
dc.date.available	2018-06-28T01:03:28Z	-
dc.date.issued	2015	-
dc.identifier.other	http://dx.doi.org/10.1016/j.physbeh.2016.07.013	-
dc.identifier.uri	http://hdl.handle.net/20.500.12222/179	-
dc.description	Besides the well-known roles of oxytocin on birth, maternal bonding, and lactation, recent evidence shows that this hypothalamic hormone possesses cardioprotective, anti-inflammatory and parasympathetic neuromodulation properties. In this study, we explore the heart rate fluctuations (HRF) in an endotoxemic rodent model that was accompanied by the administration of exogenous oxytocin. The assessment of HRF has been widely used as an indirect measure of the cardiac autonomic function. In this context, adult male Dark Agouti rats were equipped with a telemetric transmitter to continuously and remotely measure the electrocardiogram, temperature, and locomotion. In a between-subjects experimental design, rats received the following peripheral treatment: saline solution as a vehicle (V); lipopolysaccharide (LPS); oxytocin (Ox); lipopolysaccharide + oxytocin (LPS + Ox). Linear and non-linear parameters of HRF were estimated starting 3 h before to 24 h after treatments. Our results showed that exogenous oxytocin does not modify by itself the HRF of oxytocin-treated rats in comparison to vehicle-treated rats. However, in animals undergoing endotoxemia it: a) provokes a less anticorrelated pattern in HRF, b) decreased mean heart rate, c) moderated the magnitude and duration of the LPS-induced hyperthermia, and d) increased locomotion, up to 6 h after the LPS injection. The less anticorrelated pattern in the HRF and decreased mean heart rate may reflect a cardiac pacemaker coupling with cholinergic influences mediated by oxytocin during LPS-induced endotoxemia. Finally, the anti-lethargic and long-term temperature moderating effects of the administration of oxytocin during endotoxemia could be a consequence of the systemic anti-inflammatory properties of oxytocin	es_MX
dc.format	application/pdf	es_MX
dc.language	eng	es_MX
dc.publisher	Elsevier	es_MX
dc.publisher	International Behavioral Neuroscience Society	es_MX
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	https://www.elsevier.com/about/our-business/policies/sharing	es_MX
dc.rights.uri	Se autoriza la reproducción total o parcial de los textos aquí publicados siempre y cuando sea sin fines de lucro y se cite la fuente completa y la dirección electrónica de la publicación.	es_MX
dc.subject	MEDICINA Y CIENCIAS DE LA SALUD	es_MX
dc.title	Exogenous oxytocin reduces signs of sickness behavior and modifies heart rate fluctuations of endotoxemic rats	es_MX
dc.type	article	es_MX
dc.rights.license	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.rights.license	info:eu-repo/semantics/restrictedAccess	es_MX
dc.subject.keywords	Heart Rate Variability	es_MX
dc.subject.keywords	Sickness Behavior	es_MX
dc.subject.keywords	Autonomic Activity	es_MX
dc.subject.keywords	Anti-Inflammatory Cholinergic	es_MX
dc.subject.keywords	Pathway	es_MX
dc.subject.keywords	Oxytocin	es_MX
dc.subject.keywords	LPS	es_MX
dc.type.version	info:eu-repo/semantics/publishedVersion	es_MX
dc.coverage	SZ	es_MX
dc.audience	researchers	es_MX
dc.identificador.materia	3	es_MX
dc.source.other	Physiology and Behavior, vol.165 (2015)	es_MX
dc.source.other	ISSN: 0031-9384	es_MX
Aparece en las colecciones:	Artículos Científicos

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