1. XOGI Repositorio Institucional de la UAM Lerma
  2. Producción Científica y Artística
  3. Artículos Científicos
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.12222/172
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.authorJean-Pascal Morin, 0000-0001-8221-4982-
dc.contributor.authorGustavo Pacheco-Lopez, 0000-0002-3458-197X-
dc.contributor.authorFederico Bermudez_Rattoni, 0000-0003-2056-6119-
dc.contributor.otherCerón Solano, Giovanni-
dc.contributor.otherVelázquez Campos, Giovanna-
dc.contributor.otherDíaz Cintra, Sofía-
dc.date.accessioned2018-06-27T02:32:40Z-
dc.date.available2018-06-27T02:32:40Z-
dc.date.issued2016-
dc.identifier.urihttp://hdl.handle.net/20.500.12222/172-
dc.descriptionDysfunction of synaptic communication in cortical and hippocampal networks has been suggested as one of the neuropathological hallmarks of the early stages of Alzheimer’s disease (AD). Also, several lines of evidence have linked disrupted levels of activity-regulated cytoskeletal associated protein (Arc), an immediate early gene product that plays a central role in synaptic plasticity, with AD “synaptopathy”. The mapping of Arc expression patterns in brain networks has been extensively used as a marker of memory-relevant neuronal activity history. Here we evaluated basal and behavior-induced Arc expression in hippocampal networks of the 3xTg-AD mouse model of AD. The basal percentage of Arc-expressing cells in 10-month-old 3xTg-AD mice was higher than wild type in CA3 (4.88% versus 1.77% , respectively) but similar in CA1 (1.75% versus 2.75% ). Noteworthy, this difference was not observed at 3 months of age. Furthermore, although a Morris water maze test probe induced a steep (∼4-fold) increment in the percentage of Arc+ cells in the CA3 region of the 10-month-old wild-type group, no such increment was observed in age-matched 3xTg-AD, whereas the amount of Arc+ cells in CA1 increased in both groups. Further, we detected that CA3 neurons with amyloid-β were much more likely to express Arc protein under basal conditions. We propose that in 3xTg-AD mice, intraneuronal amyloid-β expression in CA3 could increase unspecific neuronal activation and subsequent Arc protein expression, which might impair further memory-stabilizing processes.es_MX
dc.formatapplication/pdfes_MX
dc.languageenges_MX
dc.publisherUniversidad Autónoma Metropolitana. Unidad Lermaes_MX
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.eses_MX
dc.rights.uriSe autoriza la reproducción total o parcial de los textos aquí publicados siempre y cuando sea sin fines de lucro y se cite la fuente completa y la dirección electrónica de la publicación.es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.titleSpatial memory impairment is associated with intraneural amyloid-? immunoreactivity and dysfunctional arc expression in the hippocampal-CA3 region of a transgenic mouse model of Alzheimer’s diseasees_MX
dc.typepreprintes_MX
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.rights.licenseinfo:eu-repo/semantics/openAccesses_MX
dc.subject.keywordsActivity Regulated Cytoskeletales_MX
dc.subject.keywordsAssociated Proteines_MX
dc.subject.keywordsAlzheimer’s Diseasees_MX
dc.subject.keywordsHippocampuses_MX
dc.subject.keywordsMemoryes_MX
dc.subject.keywordsNeuroplasticityes_MX
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_MX
dc.coverageMXes_MX
dc.audienceresearcherses_MX
dc.identificador.materia3es_MX
Aparece en las colecciones: Artículos Científicos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
000078.pdf481.83 kBAdobe PDFVisualizar/Abrir
000078.xml1.15 MBXMLVisualizar/Abrir


Este ítem está protegido por copyright original

Visualizar la licencia
Mostrar el registro sencillo del ítem Recomiende este ítem


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons