Stem cell models : a guide to understand and mitigate aging?

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.12222/162

Título :	Stem cell models : a guide to understand and mitigate aging?
Autor(es) :	Regina Brunauer, 0000-0001-9384-5501; Silvestre Alavez, 0000-0002-9220-0696
Autor(es) sin ID:	Kennedy, Brian
Fecha de publicación :	2017
Tipo de resultado Científico:	preprint
Materia o Disciplina:	MEDICINA Y CIENCIAS DE LA SALUD
Palabras clave:	Reprogramming; Stem cells; Progeria; Aging
Descripción :	Aging is studied either on a systemic level using life span and health span of animal models, or on the cellular level using replicative life span of yeast or mammalian cells. While useful in identifying general and conserved pathways of aging, both approaches provide only limited information about cell-type specific causes and mechanisms of aging. Stem cells are the regenerative units of multicellular life, and stem cell aging might be a major cause for organismal aging. Using the examples of hematopoietic stem cell aging and human pluripotent stem cell models, we propose that stem cell models of aging are valuable for studying tissue-specific causes and mechanisms of aging and can provide unique insights into the mammalian aging process that may be inaccessible in simple model organisms.
Editor:	Universidad Autónoma Metropolitana. Unidad Lerma
URI :	http://hdl.handle.net/20.500.12222/162
Condiciones de licencia:	http://creativecommons.org/licenses/by-nc-nd/4.0/
Aparece en las colecciones:	Artículos Científicos

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