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dc.contributor.authorRegina Brunauer, 0000-0001-9384-5501-
dc.contributor.authorSilvestre Alavez, 0000-0002-9220-0696-
dc.contributor.otherKennedy, Brian-
dc.date.accessioned2018-06-27T00:43:48Z-
dc.date.available2018-06-27T00:43:48Z-
dc.date.issued2017-
dc.identifier.otherhttp://dx.doi.org/10.1159/000449501-
dc.identifier.urihttp://hdl.handle.net/20.500.12222/162-
dc.descriptionAging is studied either on a systemic level using life span and health span of animal models, or on the cellular level using replicative life span of yeast or mammalian cells. While useful in identifying general and conserved pathways of aging, both approaches provide only limited information about cell-type specific causes and mechanisms of aging. Stem cells are the regenerative units of multicellular life, and stem cell aging might be a major cause for organismal aging. Using the examples of hematopoietic stem cell aging and human pluripotent stem cell models, we propose that stem cell models of aging are valuable for studying tissue-specific causes and mechanisms of aging and can provide unique insights into the mammalian aging process that may be inaccessible in simple model organisms.es_MX
dc.formattext/pdfes_MX
dc.languageenges_MX
dc.publisherUniversidad Autónoma Metropolitana. Unidad Lermaes_MX
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.titleStem cell models : a guide to understand and mitigate aging?es_MX
dc.typepreprintes_MX
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.rights.licenseinfo:eu-repo/semantics/openAccesses_MX
dc.subject.keywordsReprogramminges_MX
dc.subject.keywordsStem cellses_MX
dc.subject.keywordsProgeriaes_MX
dc.subject.keywordsAginges_MX
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_MX
dc.coverageMXes_MX
dc.audienceresearcherses_MX
dc.identificador.materia3es_MX
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