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dc.contributor.authorDaniel Osorio-Gómez, 0000-0001-8325-8506-
dc.contributor.authorFederico Bermudez_Rattoni, 0000-0003-2056-6119-
dc.contributor.authorKioko Guzmán-Ramos, 0000-0002-5180-4127-
dc.date.accessioned2018-06-26T06:10:11Z-
dc.date.available2018-06-26T06:10:11Z-
dc.date.issued2016-
dc.identifier.otherhttp://dx.doi.org/10.1101/lm.042895.116-
dc.identifier.urihttp://hdl.handle.net/20.500.12222/149-
dc.descriptionThe insular cortex (IC) is required for conditioned taste aversion (CTA) retrieval. However, it remains unknown which cortical neurotransmitters levels are modified upon CTA retrieval. Using in vivo microdialysis, we observed that there were clear elevations in extracellular glutamate, norepinephrine, and dopamine in and around the center of the gustatory zone of the IC during CTA retrieval. Additionally, it has been reported that the amygdala–IC interaction is highly involved in CTA memory establishment. Therefore, we evaluated the effects of infusions of an AMPA receptor antagonist (CNQX) and a NMDA receptor antagonist (APV) into the amygdala on CTA retrieval and IC neurotransmitter levels. Infusion of APV into the amygdala impaired glutamate augmentation within the IC, whereas dopamine and norepinephrine levels augmentation persisted and a reliable CTA expression was observed. Conversely, CNQX infusion into the amygdala impaired the aversion response, as well as norepinephrine and dopamine augmentations in the IC. Interestingly, CNQX infusion did not affect glutamate elevation in the IC. To evaluate the functional meaning of neurotransmitters elevations within the IC on CTA response, we infused specific antagonists for the AMPA, NMDA, D1, and β-adrenergic receptor before retrieval. Results showed that activation of AMPA, D1, and β-adrenergic receptors is necessary for CTA expression, whereas NMDA receptors are not involved in the aversion response.es_MX
dc.formatapplication/pdfes_MX
dc.languageenges_MX
dc.publisherCold Spring Harbor Laboratory Presses_MX
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_MX
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_MX
dc.titleMemory trace reactivation and behavioral response during retrieval are differentially modulated by amygdalar glutamate receptors activity: Interaction between amygdala and insular cortexes_MX
dc.typearticlees_MX
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.rights.licenseinfo:eu-repo/semantics/openAccesses_MX
dc.subject.keywordsCorteza insulares_MX
dc.subject.keywordsMicrodiálisises_MX
dc.subject.keywordsNeurotransmisores corticaleses_MX
dc.subject.keywordsGlutamato extracelulares_MX
dc.subject.keywordsNorepinefrinaes_MX
dc.subject.keywordsDopaminaes_MX
dc.subject.keywordsAmígdala-ICes_MX
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_MX
dc.coverageUSes_MX
dc.audienceresearcherses_MX
dc.identificador.materia3es_MX
dc.source.otherLearning & Memory, vol.24 (2016)es_MX
dc.source.otherISSN: 1072-0502es_MX
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